Pro-cathepsin L, Cathepsin L1, Major excreted protein, MEP

Human

CSI19795B pdf (datasheet)

100 μg

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The most powerful of the lysosomal proteases. Cathepsin L has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. Specificity close to that of papain.

The level of cathepsin L is a strong predictor of relapse and survival following treatment of a primary breast tumor.

≥ 1.0 mg/ml, lot specific

Pro-cathepsin L

P07711

CSI19795

Human liver

25-29 kDa

20 mM Malonate, 400 mM NaCl, 1 mM EDTA, pH 5.5

>95% by SDS-PAGE analysis

One unit is defined as the amount of enzyme that hydrolyzes one micromole of Z-Phe-Arg-AFC per minute at 25°C using 400 mM Na Acetate, pH 5.5 with 4 mM EDTA and 8 mM DTT as the activation buffer in the presence of Brij.

> 1 unit per mg protein

Store at -80°C for up to 1 year. Upon initial thaw, prepare working aliquots and store at -80°C. Avoid repeated freeze-thaw cycles.