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  • Native Human Cathepsin D, Liver

Native Human Cathepsin D, Liver

Synonyms:

Cathepsin D, CTSD

Species:

Human

Cat. No.:

CSI19793A pdf (datasheet)

Quantity/Size:

25 μg

Price:

$300.00 BUY

Description:

Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node-negative and node-positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer's plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.

Entrez Symbol:

CTSD

Uniprot Name:

Cathepsin D

Uniprot ID:

P07339

Data PDF:

CSI19793

Source:

Human liver

Molecular Weight:

42 kDa

Formulation:

Lyophilized from 2 mM sodium phosphate, pH 6.5.

Purity:

≥ 95% by SDS-PAGE analysis

Biological Activity:

One unit is defined as the amount of enzyme that digests hemoglobin-releasing peptides which are soluble in 10% TCA. The reaction is measured by an increase of an A280 of 1.0 per 60 minutes at 37°C.
Substrate: acid denatured hemoglobin, pH 1.8 (0.2% in reaction mixture).
Buffer: 100 mM formate, pH 3.3.

Specific Activity:

≥300 units/mg

Reconstitution:

Centrifuge vial prior to opening. Add deionized water to 0.1-1.0 mg/ml.

Storage/Stability:

Store at -80°C for up to 1 year. Upon reconsitution, prepare working aliquots and store at -80°C. Avoid repeated freeze-thaw cycles.