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Native Human Complement C4c

Synonyms:

Complement C4-B, Basic complement C4

Species:

Human

Cat. No.:

CRC163B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$280.00 BUY

Description:

Complement C4 (C4) plays a central role in both the classical and lectin pathways of complement activation, with levels in human plasma ~0.4 mg/ml. C4 circulates in human plasma as a heterotrimer of 205 kDa in plasma, α (93 kDa), β (78 kDa), and γ (33 kDa). During complement activation, C4 is cleaved by the serine protease C1s to C4a (9 kDa) and C4b (190 kDa). C4b is further cleaved by factor I to C4d (45 kDa) and C4c (140 kDa). The current protocol yields C4c, however intact C4 and/or C4b and C4d may be co-purified.

Entrez Symbol:

C4B

Uniprot Name:

Complement C4-B

Uniprot ID:

P0C0L5

Data PDF:

CRC163

Source:

Human plasma

Molecular Weight:

147 kDa

Formulation:

PBS, pH 7.4

Purity:

>85% by SDS-PAGE

Storage/Stability:

Store as supplied at -80°C for up to 1 year.

Application notes:

Western blot: reacts with C4 antisera

Not biologically active.