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Mouse Anti-Human MMP10 mAb

Molecule:

MMP10

Synonyms:

Stomelysin 2, SL-2, Matrix metalloproteinase 10, MMP-10, Transin-2

Species:

Human

Cat. No.:

CMM109 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$800.00 BUY

Description:

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP10 (stromelysin 2) degrades a broad range of substrates including gelatin, collagen types III, IV and V, fibronectin, aggrecan, and pig cartilage proteoglycan. MMP10 can activate other MMPs such as MMP1 and MMP8. MMP10 is expressed in keratinocytes, T cells, menstrual endometrium and a few tumor samples. Structurally, MMP10 may be divided into four distinct domains: a prodomain which is cleaved upon activation, a catalytic domain containing the zinc binding site; a short linker region, and a carboxyl terminal hemopexin- like domain.

Uniprot Name:

Stomelysin 2

Uniprot ID:

P09238

Data PDF:

CMM109

Specificity:

Recognizes human MMP-10

Host Species:

Mouse

Immunogen:

Recombinant human MMP-10

Isotype:

IgG2

Clone:

9G10

Formulation:

Lyophilized from sterile filtered PBS

Purification:

Protein G affinity chromatography

Reconstitution:

Centrifuge vial prior to opening. Reconstitute the antibody with 500 μl sterile PBS to a final concentration of 200 μg/ml.

Application notes:

Western Blot: suggested dilution 1:1000
IHC-P:suggested dilution 1:50-1:300

Storage/Stability:

Lyophilized antibody is stable for at least 1 year from date of receipt at -80°C. Reconstituted antibody is stable in working aliquots at -80°C for at least six months. Avoid repeated freeze-thaw cycles.