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Research Grade Ziltivekimab

Synonyms:

Interleukin-6, B-cell stimulatory factor 2, BSF-2, CTL differentiation factor, CDF, Hybridoma growth factor, Interferon beta-2, IFN-beta-2

Cat. No.:

DHC15802A pdf (datasheet)

Quantity/Size:

100 ug

Price:

$380.00 BUY

Concentration:

1.0 mg/ml, lot specific

Description:

Ziltivekimab is a humanized monoclonal antibody directed against the IL-6 ligand. It was developed to inhibit pro-inflammatory IL-6 signaling in conditions that are associated with systemic inflammation, including atherosclerosis, chronic kidney disease, and rheumatoid arthritis, and it has also been explored for anti-tumor activity. The Fc domain of ziltivekimab has been engineered to extend its half-life by increasing affinity for FcRn.

Uniprot Name:

Interleukin-6

Uniprot ID:

P05231

Purity:

> 95% as determined by SDS-PAGE

Specificity:

Human IL-6

Isotype:

IgG1 Kappa light chain

Formulation:

0.01M PBS, pH 7.4

Purification:

Protein A/G affinity chromatography

Storage/Stability:

Recommended storage, undiluted at 2-8°C for up to 1 week, or in working aliquots at -20°C to -80°C for up to 1 year. Avoid freeze/thaw cycles.