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Research Grade Omburtamab

Synonyms:

CD276 antigen, 4Ig-B7-H3, B7 homolog 3, B7H3, Costimulatory molecule, Mab 8H9

Cat. No.:

DHJ04002A pdf (datasheet)

Quantity/Size:

100 ug

Price:

$380.00 BUY

Concentration:

1.0 mg/ml, lot specific

Description:

Omburtamab is derived from the murine monoclonal Mab 8H9 developed from mice immunized with human neuroblastoma. Clone 8H9 has a high affinity for B7H3 (CD276), a tumor-associated surface immunomodulatory glycoprotein and was shown to bind the FG loop of B7-H3. B7-H3 is widely expressed among solid tumors and is strongly correlated with recurrence, metastasis, and death. Omburtamab was under investigation for the treatment of metastatic brain cancer, now under clinical development for other cancer immunotherapies.

Entrez Symbol:

CD276

Uniprot Name:

CD276 antigen

Uniprot ID:

Q5ZPR3

Data PDF:

DHJ04002

Purity:

> 95% as determined by SDS-PAGE

Specificity:

Human CD276 / B7H3

Host Species:

Mouse

Isotype:

IgG1 Kappa light chain

Formulation:

0.01M PBS, pH 7.4

Purification:

Protein A/G affinity chromatography

Application:

FC, FS

Storage/Stability:

Recommended storage, undiluted at 2-8°C for up to 1 week, or in working aliquots at -20°C to -80°C for up to 1 year. Avoid freeze/thaw cycles.