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Research Grade Glofitamab

Synonyms:

Bispecific, CD20-TCB (2:1), RG-6026, CAS: 2229047-91-8

Cat. No.:

DHC90714B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,030.00 BUY

Concentration:

1.0 mg/ml, lot specific

Description:

Research Grade Glofitamab is a bispecific humanized monoclonal antibody possessing a novel 2:1 structure with bivalency for CD20 on B cells and monovalency for CD3 on T cells. Glofitamab is an investigational, T-cell bispecific antibody with a distinctive design that features 2 Fab arms for binding CD20 on B cells, along with 1 Fab arm for binding CD3 on T cells. The CD3 binding arm is fused directly to one of the CD20-binding arms in a head-to-tail fashion via a short flexible linker.

Uniprot Name:

B-lymphocyte antigen CD20, T-cell surface glycoprotein CD3 epsilon chain

Uniprot ID:

P11836, P07766

Purity:

> 95% as determined by SDS-PAGE

Specificity:

Human B-lymphocyte antigen CD20 & T-cell surface glycoprotein CD3 epsilon chain

Host Species:

Human

Isotype:

IgG1-kappa-lambda

Formulation:

0.01M PBS, pH 7.4

Purification:

Protein A/G affinity chromatography

Storage/Stability:

Recommended storage, undiluted at 2-8°C for up to 1 week, or in working aliquots at -20°C to -80°C for up to 1 year. Avoid freeze/thaw cycles.