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Research Grade Anti-SARS-CoV-2 Spike-RBD (S2H97) mAb

Synonyms:

Spike glycoprotein, Spike receptor binding domain, Spike-RB protein, S2H97

Species:

SARS-CoV-2

Cat. No.:

DVV00317B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$1,520.00 BUY

Concentration:

1.0 mg/ml, lot specific

Description:

S2H97 is a fully human anti-SARS-CoV-2 monoclonal antibody originally derived from COVID-19 convalescent plasma, selected based on its potential to neutralize the virus in vitro, including variant Omicron. S2H97, binds with high affinity across all sarbecovirus clades to a cryptic epitope and prophylactically protects from viral challenge. The exceptionally cross-reactive S2H97 antibody targets a previously undescribed cryptic antigenic site. S2H97 binding is facilitated by packing of the heavy chain complementarity-determining region 3 (CDR3) into an RBD crevice at the center of the epitope, together with polar contacts with all three heavy chain CDRs and the light chain CDR2. Antibodies that target the angiotensin-converting enzyme 2 (ACE2) receptor-binding motif (RBM) typically have poor breadth and are readily escaped by mutations despite high neutralization potency.

Entrez Symbol:

S

Uniprot Name:

Spike glycoprotein

Uniprot ID:

P0DTC2-2

Data PDF:

DVV00317

Purity:

> 95% by SDS-PAGE

Specificity:

Recognizes SARS-CoV-2 Spike-RBD (2019-nCoV) conserved epitope

Host Species:

Human

Isotype:

IgG1 Kappa light chain

Clone:

S2H97

Formulation:

Sterile-filtered 0.01M PBS, pH 7.4 preservative free.

Purification:

Protein A affinity chromatography

Application:

FS , Functional assay, Neutralizing

Storage/Stability:

Store at -20°C to -80°C.