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Vaccinia virus cell surface-binding protein OPG105 binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell.Vaccinia virus is a large, double-stranded DNA virus that carries out its entire replication cycle in the cytoplasm of infected cells. The virus is in the same family as variola virus, the causative agent of smallpox, and immunization with a vaccine derived from vaccinia virus provides protection against smallpox, monkeypox, and other members of the orthopoxvirus family.