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Recombinant SARS-Associated Coronavirus Spike Mosaic S(M) (aa 408-470, 540-573)

Synonyms:

SARS-ACSMS(M)

Cat. No.:

CSI13609 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$900.00 BUY

Description:

SARS-ACSMS(M) contains the middle section of the Spike protein immunodominant fragments, amino acids: 408-470, 540-573.

The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. It is a type 1 viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N and HR-C, that form coiled-coil structures within the ectodomain of the protein. Previous studies have shown that the two heptad repeat regions can undergo a conformational change from their native state to a 6-helix bundle (trimer of dimers), which mediates fusion of viral and host cell membranes .

Data PDF:

CSI13609

Source:

E. coli

Molecular Weight:

38 kDa

Formulation:

25 mM Tris-HCl, 0.4% sarcosyl, 0.25% Triton X-100 and 50% glycerol

Purity:

> 95% by SDS-PAGE

Storage/Stability:

Store at -80°C for up to 1 year. Upon initial thaw, prepare aliquots and store at -80°C. Avoid freeze / thaw cycles

Application notes:

Recombinant SARS-ACN Antigen may be used in ELISA and Western blots, excellent for detection of SARS with minimal specificity problems.

Application:

ELISA, WB