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Recombinant Mouse Thrombopoietin

Synonyms:

Thpo, C-mpl ligand, Megakaryocyte colony-stimulating factor, MGDF, Myeloproliferative leukemia virus oncogene ligand

Species:

Mouse

Cat. No.:

CSI12329 pdf (datasheet)

Quantity/Size:

10 μg

Price:

$670.00 BUY

Description:

TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits crossspecies reactivity. Recombinant murine TPO is fully biologically active and contains the erythropoietin-like domain of the full length TPO protein.

Entrez Symbol:

Thpo

Uniprot ID:

P40226

Data PDF:

CSI12329

Source:

E. coli

Molecular Weight:

18.7 kDa (174 aa)

Formulation:

Sterile filtered and lyophilized from 10 mM Tris, pH 8.0.

Purity:

>98% by SDS-PAGE and HPLC analyses.

Biological Activity:

ED50 < 1.0 ng/ml, determined by the dose-dependent stimulation of the proliferation of human MO7e cells.

Endotoxin Level:

< 1 EU//µg

Amino Acid Sequence:

SPVAPACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSK AQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPLQGRT TAHKDPNALFLSLQQLLRGKVRFLLLVEGPTLCVRRTLPTTAVPSSTSQLLTLNKF

Storage/Stability:

Stable for 1 year at -20°C to -80°C.