Progranulin, PGRN, Acrogranin, Epithelin/granulin precursor, Glycoprotein of 88 Kda, GP88, Glycoprotein 88, PC cell-derived growth factor, PCDGF, Proepithelin, PEPI

Mouse

CRM033A pdf (datasheet)

10 μg

$270.00 BUY

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Recombinant Mouse Progranulin is composed of a signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional aa.

Progranulin

P28798

CRM033

HEK293 cells

~90 kDa (glycosylated) by SDS-PAGE

Lyophilized from PBS

≥95% (SDS-PAGE)

<0.01 EU/μg purified protein as determined by LAL test (Lonza)

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/mL and gently pipette the solution up and down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution.

Upon receipt, store lyophilized product at -20°C to -80°C for at least 6 months. After reconstitution, store aliquots of the stock solution at -20°C to -80°C for up to 3 months. Avoid repeated freeze-thaw cycles.