IFN-gamma

IFN-g, Interferon-gamma, IFN-γ

Mouse

CRI001B-AF pdf (datasheet)

100 µg

$240.00 BUY

Interferon gamma (IFN-g) is a soluble cytokine and a type II interferon. IFN-g is secreted by innate and adaptive immune cells. The active protein is a homodimer that binds to the IFN-g receptor, which triggers a cellular response to viral and microbial infections. IFN-g exerts antiproliferative, immunoregulatory and proinflammatory activities and induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. Additionally, IFN-g augments TH1 cell expansion and may be required for TH1 cell differentiation.
Mouse IFN-γ is not cross-reactive with human IFN-γ.
Made without animal-derived components, using animal-free equipment and protocols.

CRI001-AF

E. coli

15.7 kDa (134 aa), monomer

Lyophilized from a sterile-filtered aqueous solution containing 10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5

> 95% by reducing and non-reducing SDS-PAGE

< 1 ng/ml, by viral CPE assay using EMC virus on L929 cells.

> 1 x 10⁶ U/mg

≤ 0.1 EU/µg of protein by kinetic LAL analysis.

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein such as 0.1% HSA or BSA is added for long term storage. Avoid repeated freeze-thaw cycles.