Recombinant Mouse IFN-beta

Molecule:

IFN-beta

Synonyms:

Inteferon beta 1 fibroblast, IFN-beta, IFNB, IFB

Species:

Mouse

Cat. No.:

CR2039 pdf (datasheet)

Quantity/Size:

100 µl

Price:

$600.00 BUY

Description:

Interferon beta (IFN-b) belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. IFN-b belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for the IFN-beta gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection.

Concentration:

>1 x 106 units/ml, lot specific

Uniprot Name:

Interferon beta

Uniprot ID:

P01575

Data PDF:

CR2039

Source:

E. coli

Molecular Weight:

19.6 kDa

Formulation:

20 mM HEPES, pH 6.0, 0.5 M NaCl, 6% Glycerol

Purity:

> 95% by SDS-PAGE

Biological Activity:

EC50 ~ 2.5 U/ml, determined in a cytopathic effect inhibition assay using mouse L929 cells with encephalomyocarditis virus (EMCV).Activity units were determined relative to a lab standard of mouse IFN-beta which was calibrated to the NIH Mouse IFN-beta standard.

Specific Activity:

~1 x 107 U/mg

Endotoxin Level:

<1 EU/µg IFN-beta

Storage/Stability:

Upon receipt store product at -80°C for retention of full activity. After initial thaw (in cold water, until just thawed), refreeze in working aliquots. Refreeze on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA). Avoid repeated freeze-thaw cycles.