E3 ubiquitin-protein ligase TRIM21, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, 52 kDa Ro protein

Human

CSI12836 pdf (datasheet)

5 μg

$450.00 BUY

TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The 52 kDa Ro protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. Ro/SSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Ribonucleoprotein particle is composed of a single polypeptide and one of four small RNA molecules. The RoSSA is present in all mammalian cells studied but has no known function. At least 2 isoforms are present in nucleated and red blood cells, and tissue specific differences in Ro/SSA proteins were identified.

1.0 mg/ml, lot specific

TRIM21

E3 ubiquitin-protein ligase TRIM21

P19474

CSI12836

Sf9 insect cells

52 kDa

N-terminal 6x His tag

Sterile-filtered 20 mM HEPES pH 7.5 containing 0.01 mM EDTA, 0.02 % SDS

>95% by SDS-PAGE

Store at -20°C to -80°C