Recombinant Human tPA Immobilized

Synonyms:

Tissue-type plasminogen activator, t-PA t-plasminogen activator, tPA

Species:

Human

Cat. No.:

CRT185B pdf (datasheet)

Quantity/Size:

1 ml packed resin

Price:

$1,230.00 BUY

Description:

Tissue-type plasminogen activator (tPA) is a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The tPA pre-pro-protein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Recombinant Human single-chain tPA immobilized on agarose resin may be used to immunopurify monoclonal and polyclonal antibodies directed against human tPA and for controlled plasminogen activation studies. May be used repeatedly.

Concentration:

2.0 mg/ml coupled, lot specific

Entrez Symbol:

PLAT

Uniprot Name:

Tissue-type plasminogen activator

Uniprot ID:

P00750

Data PDF:

CRT185B

Source:

CHO cells

Molecular Weight:

70 kDa

Formulation:

1:1 slurry in 0.1 M HEPES, 0.1 M NaCl, 0.02% sodium azide, pH 7.4

Purity:

> 95% by SDS-PAGE

Storage/Stability:

Store at 2-8°C for up to 1 year.