Recombinant Human TNFRSF17 / BCMA / CD269 (Fc tag)

Synonyms:

Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein, CD269

Species:

Human

Cat. No.:

CRH524B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

Please Inquire

Description:

B cell maturation antigen or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. CD269 is a receptor for TALL-1 and activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of CD269 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. CD269 is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface CD269 may contribute directly to tumor rejection in vivo.

Entrez Symbol:

TNFRSF17

Uniprot Name:

Tumor necrosis factor receptor superfamily member 17

Uniprot ID:

Q02223

Data PDF:

CRH524

Source:

HEK293 cells

Molecular Weight:

32.2 kDa (292 aa), predicted
~37 kDa, apparent on SDS-PAGE

Tag:

Silent human IgG1 Fc tag (Pro100-Lys330)

Formulation:

Sterile filtered PBS, pH 7.4

Purity:

> 90 % as determined by SDS-PAGE

Storage/Stability:

Stable for up to 1 year from date of receipt at -20°C to -80°C After reconstitution, store working aliquots at -20°C to -80°C. Avoid repeated freeze-thaw cycles.

Application notes:

Recognized by anti-BCMA CDM545 in ELISA