Synonyms:
Tumor necrosis factor ligand superfamily member 15, TNFSF15, TNF15, TNF ligandrelated molecule 1, Vascular endothelial cell growth inhibitor, , Human Recombinant TNF Ligand-related molecule 1, TL-1A, TL1A
Description:
TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6.
Molecular Weight:
22 kDa (194 aa)
Formulation:
Lyophilized from PBS
Purity:
>98% by HPLC and SDS-PAGE
Biological Activity:
Determined by its ability to stimulate IFN-γ production by human PBMC using a concentration range of 10.0-100.0 ng/ml. Results will vary with PBMC donors.
Endotoxin Level:
<1 EU/µg
Amino Acid Sequence:
QLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL
Storage/Stability:
Stable for 1 year at -20°C to -80°C.
