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Recombinant Human Thyroid Peroxidase

Molecule:

TPO

Synonyms:

TPO, EC:1.11.1.8

Species:

Human

Cat. No.:

CSI19712B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$500.00 BUY

Description:

Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called `microsomal antigen` has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3.

Concentration:

0.5 mg/ml, lot specific

Entrez Symbol:

TPO

Uniprot Name:

Thyroid Peroxidase

Uniprot ID:

P07202

EC number:

1.11.1.8

Data PDF:

CSI19712

Source:

Sf9 insect cells

Molecular Weight:

92.87 kDa (834 aa) predicted, 101 kDa apparent on SDS-PAGE with 6x His tag

Tag:

His

Formulation:

16mM HEPES, 160mM NaCl, 0.08 mM Kl, pH 7.6 containing 20% glycerol.

Purity:

>95% by SDS-PAGE analysis

Storage/Stability:

Store at 2-8°C for short-term use or in aliquots at -20°C to -80°C for longer term.

Application notes:

Suitable for biotinylation and iodination
Binds IgG-type human auto-antibodies.
Auto-antibodies to TPO recognize conformation-dependent epitopes.

Application:

ELISA, WB