Synonyms:
Tryptophan 2,3-dioxygenase, TDO, Tryptophan oygenase, Tyrptophan pyrrolase, Tryptophanase
Description:
The tetramer binds two molecules of protoheme IV. It is a homotetramer involved in tryptophan catabolism. There is a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of anti tumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.
Uniprot Name:
Tryptophan 2,3-dioxygenase
Molecular Weight:
46.7 kDa (aa 1-406)
Formulation:
10 mM Tris, pH 8.0 containing 0.1% Triton X-10, 0.002% NaN3 and 10 mM DTT
Storage/Stability:
Store as supplied at -20°C to -80°C for up to 1 year. Upon initial thaw, prepare working aliquots and store at -20°C to -80°C. Avoid repeated freeze-thaw cycles.
Application:
ELISA, MS, WB
