Synonyms:
Histone-lysine N-methyltransferase SETD7, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase, SET domain-containing protein 7, SET7/9.
Cat. No.:
CSI12697C
pdf (datasheet)
Description:
SET7/9 is a histone methyltransferase (HMTase) that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine (AdoMet). The methylation of lysine residues of histones plays a critical role in the regulation of chromatin structure and gene expression.
Acetylation, phosphorylation and methylation of the amino-terminal tails of histone are thought to be involved in the regulation of chromatin structure and function. The enzymes identified in the methylation of specific lysine residue on histones belong to the SET family with just one exception. SET7/9, unlike most other SET proteins, is exclusively a mono-methylase.
Uniprot Name:
Histone-lysine N-methyltransferase SETD7
Molecular Weight:
40.7 kDa, 366 aa
Physical State:
Sterile filtered liquid
Formulation:
50 mM Tris-HCl buffer, pH 7.5, 0.2 M NaCl, 5 mM DTT with 20% glycerol.
Purity:
> 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK
Storage/Stability:
Store at -20°C to -80°C
