PGRN, Acrogranin, Epithelin precursor, Glycoprotein 88, GP88, Granulin precursor, PC cell-derived growth factor, PCDGF, Proepithelin, PEPI

Human

CRH027A pdf (datasheet)

10 μg

$270.00 BUY

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Recombinant Human Progranulin is composed of a signal peptide and aa 1-593 of human progranulin fused. The protein reflects the native sequence with no additional aa. The final Progranulin product consists of aa 18-593.

Progranulin

P28799

CRH027i

HEK293 cells

~90 kDa by SDS-PAGE

Lyophilized from PBS.

≥98% (SDS-PAGE)

Binds to human sortilin. Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight.

<0.01 EU/μg purified protein as determined by LAL test (Lonza).

Lyophilized product is stable for at least 6 months after receipt when stored at -20°C to -80°C. Following reconstitution, working aliquots are stable at -20°C to -80°C for up to 3 months. Avoid repeated freeze-thaw cycles.