Heparin-binding brain mitogen, HBBM, Heparin-binding growth factor 8, Osteoblastspecifc factor 1, OSF-1

Human

CRH325C-AF pdf (datasheet)

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Pleiotrophin (PTN) is a heparin-binding growth factor that has mitogenic effects on fibroblast, epithelial, and endothelial cells. PTN is made by many tissues, but is predominantly secreted by nervous tissue during development. PTN induces neurite outgrowth and is involved in tumor growth and metastasis. PTN binds with low affinity to the cell surface receptor nucleolin to inhibit HIV-1 infection. PNT also binds the receptor protein tyrosine phosphatase type Z (PTPRZ), syndecan-3, and anaplastic lymphoma kinase (ALK) receptors.

Manufactured without Animal-derived products, in an Animal Free facility.

P21246

E. coli

Monomer, 15.4 kDa (137 aa)

Lyophilized from a sterile-filtered solution containing 10 mM sodium phosphate, pH 7.5

≥95% by reducing and non-reducing SDS-PAGE

≤1 EU/µg by kinetic LAL analysis

MGKKEKPEKK VKKSDCGEWQ WSVCVPTSGD CGLGTREGTR TGAECKQTMK TQRCKIPCNW KKQFGAECKY QFQAWGECDL NTALKTRTGS LKRALHNAEC QKTVTISKPC GKLTKPKPQA ESKKKKKEGK KQEKMLD

Centrifuge vial prior to opening. Add sterile distilled water to a concentration of 0.1 mg/mL and gently pipetting the solution up and down the sides of the vial. DO NOT VORTEX. Allow several minutes for reconstitution. A small amount of precipitate may be seen.

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein such as 0.1% HSA or BSA is added for long term storage. Avoid repeated freeze-thaw cycles.