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Recombinant Human Neuregulin-1-beta2 EGF-like Domain

Molecule:

NRG1

Synonyms:

Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, Neuregulin-1

Species:

Human

Cat. No.:

CRN005C pdf (datasheet)

Quantity/Size:

500 µg

Price:

$950.00 BUY

Description:

Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that recombinant neuregulin could make disturbed myocardial cell structure into order and strengthen the connection between myocardial cells by intercalated discs re-organization.

Entrez Symbol:

NRG1

Uniprot Name:

Pro-neuregulin-1, membrane-bound isoform

Uniprot ID:

Q02297

Data PDF:

CRN005

Source:

E. coli

Molecular Weight:

~7.0 kDa (61 aa) monomer

Formulation:

Lyophilized from sterile-filtered PBS, pH 7.4

Purity:

>96.0% by HPLC and SDS-PAGE

Biological Activity:

ED50, < 5.0 ng/ml, determined by dose-dependent cell proliferation assay using serum free human MCF-7 cells.

Specific Activity:

> 2.0 × 10e5 U/mg

Endotoxin Level:

< 1 EU/μg protein as determined by LAL method

Amino Acid Sequence:

SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKAEELY Q

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/mL. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

Store at -20°C to -80°C for 1 year.