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Recombinant Human MARK4, Active GST Tag

Synonyms:

MAP/microtubule affinity-regulating kinase 4, MAP/microtubule affinity-regulating kinase-like 1

Species:

Human

Cat. No.:

CSI13435 pdf (datasheet)

Quantity/Size:

10 μg

Price:

$425.00 BUY

Description:

Recombinant human full length MARK4 was expressed by baculovirus in Sf9 cell with a N-terminal GST tag. MARK4 or microtubule affinity-regulating kinase 4 is a member of the Par-1 family of serine/threonine protein kinases. MARK4 is predominantly expressed in the brain and readily phosphorylates Tau, MAP2 and MAP4. MARK4 co-localizes with the centrosome and microtubules in cultured cells. Overexpression of MARK4 causes thinning out of the microtubule network concomitant with the reorganization of microtubules into bundles. MARK4 provides a growth advantage to cells and the up-regulation of this kinase during focal ischemia may represent a new therapeutic target. MARK4 is expressed during the cell cycle and is linked to aberrant centrosomes in glioma cells.

Concentration:

0.1 mg/ml

Entrez Symbol:

MARK4

Uniprot Name:

MAP/microtubule affinity-regulating kinase 4

Uniprot ID:

Q96L34

Data PDF:

CSI13435

Source:

Insect cells

Molecular Weight:

~104 kDa

Formulation:

50mM Tris, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM, 25% glycerol

Purity:

> 80% by SDS-PAGE

Specific Activity:

1,140 nmol/min/mg using CHKtide peptide substrate (KKKVSRSGLYRSPMPENLNRPR)

Storage/Stability:

Store at -80°C.