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Recombinant Human Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF)

Synonyms:

Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, MANF

Species:

Human

Cat. No.:

CS526C pdf (datasheet)

Quantity/Size:

500 µg

Price:

$1,550.00 BUY

Description:

Mesencephalic astrocyte-derived neurotrophic factor is a secreted protein that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease.
Mature human MANF is 99%, 98% and 96% a.a. identical to mature rat, mouse and bovine MANF respectively.

Entrez Symbol:

MANF

Uniprot Name:

Mesencephalic astrocyte-derived neurotrophic factor

Uniprot ID:

P55145

Data PDF:

CS526

Molecular Weight:

18.2 kDa (158 aa) monomer

Formulation:

Lyophilized from sterile filtered PBS, pH 7.4.

Purity:

>95% by SDS-PAGE and HPLC analyses.

Biological Activity:

ED50 < 20 µg/ml, determined by a cell proliferation assay using rat C6 cells

Specific Activity:

> 50 Units/mg

Endotoxin Level:

< 1 EU/μg as determined by LAL method.

Amino Acid Sequence:

LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Storage/Stability:

Store at -20°C to -80°C for up to 1 year.