Alpha-2-macroglobulin receptor-associated protein, Alpha-2-MRAP, Low density lipoprotein receptor-related protein-associated protein 1, RAP

Human

CSI19909A pdf (datasheet)

100 µg

$1,590.00 BUY

Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is an endocytic receptor for several ligands, such as alpha2-macroglobulin (alpha2 M) and apolipoprotein E. LRP is involved in the clearance of lipids from the bloodstream and is expressed in the atherosclerotic plaque. It is a receptor antagonist that interacts with several members of the low-density lipoprotein (LDL) receptor gene family. Upon binding to these receptors, LRPAP1 inhibits all ligand interactions with the receptors. LRPAP1 is present on the cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains. It binds with LRP1B and the binding is followed by internalization and degradation. LRPAP1 interacts with LRP1/alpha-2-macroglobulin receptor and LRP2 (previously called glycoprotein 330) and may be involved in the pathogenesis of membrane glomerular nephritis.

LRPAP1

Alpha-2-macroglobulin receptor-associated protein

P30533

CSI19909A

HEK293 cells

39 kDa predicted, 43 kDa on reduced SDS-PAGE

C-His

Lyophilized from sterile filtered PBS, pH 7.4

> 92% determined by reducing SDS-PAGE

< 1.0 EU/mg as determined by LAL analysis

Store at -20°C to -80°C for 1 year.