Synonyms:
Recombinant Human CCL4, LAG1, C-C motif chemokine 4, Lymphocyte activation gene 1 protein, LAG-1, Macrophage inflammatory protein 1-beta, MIP-1-beta
Description:
LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine
at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV suppressive factor.
Molecular Weight:
7.7 kDa (69 aa)
Formulation:
Lyophilized from PBS.
Purity:
> 90% by SDS-PAGE and HPLC analyses
Biological Activity:
Determined by its ability to chemoattract CCR5 transfected cells using a concentration of 0.1-10.0 ng/ml.
Endotoxin Level:
< 1 EU/µg
Amino Acid Sequence:
APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRSKQV CADPSESWVQ EYVYDLELN
Storage/Stability:
Stable for 1 year at -20°C to -80°C.
