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Recombinant Human Interleukin-18

Molecule:

IL-18

Synonyms:

Interleukin-18, IL-18, Interferon gamma-inducing factor, IGIF, Interleukin-1 gamma

Species:

Human

Cat. No.:

CRI166A pdf (datasheet)

Quantity/Size:

10 μg

Price:

$450.00 BUY

Description:

Human Interleukin-18 is a proinflammatory cytokine in the IL-1 family that exerts distinct immune effects depending on the local cytokine environment. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. The precursor is activated intracellularly by Caspase-1 mediated proteolysis to release the 17 kDa mature cytokine. The precursor can also be released by necrotic cells for extracellular cleavage by multiple proteases. IL-18 activation is induced by infection or tissue damage and contributes to disease pathology in chronic inflammation. IL-18 binds to the widely expressedIL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs.

Entrez Symbol:

IL18

Uniprot Name:

Interleukin-18

Uniprot ID:

Q14116

Data PDF:

CRI166

Source:

E. coli

Molecular Weight:

18.2 kDa (157 aa) monomer

Formulation:

Lyophilized from sterile filtered PBS, pH 7.0

Purity:

> 95% by SDS-PAGE

Biological Activity:

Testing in progress.

Endotoxin Level:

< 0.1 EU/μg as determined by LAL method.

Amino Acid Sequence:

YFGKLESKLS VIRNLNDQVL FIDQGNRPLF EDMTDSDCRD NAPRTIFIIS MYKDSQPRGM AVTISVKCEK ISTLSCENKI ISFKEMNPPD NIKDTKSDII FFQRSVPGHD NKMQFESSSY EGYFLACEKE RDLFKLILKK EDELGDRSIM FTVQNED

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.