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Recombinant Human IL-2 (C126S), Animal Free

Synonyms:

Interleukin-2, IL-2, T-cell Growth Factor, TCGF, Aldesleukin

Species:

Human

Cat. No.:

CRI101C-AF pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$775.00 BUY

Description:

Interleukin-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.

Amino acid sequence includes C126S identical to aldesleukin.

Entrez Symbol:

IL2

Uniprot Name:

Interleukin-2

Uniprot ID:

P60568

Data PDF:

CRI101-AF

Source:

E. coli

Molecular Weight:

15.5 kDa (134 aa) monomer

Formulation:

Lyophilized from sterile filtered solution containing 0.1% Trifluoroacetic Acid (TFA)

Purity:

≥97% by reducing and non-reducing SDS-PAGE, Coomassie staining

Biological Activity:

ED50 ≤ 3 ng/ml, determined by the dose-dependent proliferation of mouse CTLL-2 cells. In addition, this product has been tested for primary human T cell proliferation, with a typical ED50 < 1 ng/ml.

Endotoxin Level:

<0.01 EU/µg using USP <85>/ EP 2.6.14

Amino Acid Sequence:

MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFSQSII STLT

Reconstitution:

Centrifuge vial prior to opening. Add sterile 10 mM HCl to a concentration of 0.1 mg/mL. DO NOT VORTEX. Allow several minutes for complete reconstitution.

Storage/Stability:

Lyophilized vial is shipped at ambient temperature. Immediately upon receipt, store unopened vial at -20°C (manual defrost freezer) or -80°C for up to 36 months.