Synonyms:
Insulin-like growth factor-binding protein 4 , IGF-BP-4, IBP-4, IGFBP4
Cat. No.:
CSI12211A
pdf (datasheet)
Description:
IGFBPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGFBP4 is the major IGFBP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGFBP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGFBP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF independent pathway. The biological effects of IGFBP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGFBP4/ IGF binding affinity by proteolytically cleaving IGFBP4. The modulation of IGFBP4 activity by PAPP-A
is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells.
Molecular Weight:
25.8 kDa (257 aa)
Formulation:
Lyophilized from PBS
Purity:
> 95%, determined by RP-HPLC and SDS-PAGE analyses.
Endotoxin Level:
< 1 EU/µg
Amino Acid Sequence:
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
Storage/Stability:
Stable for 1 year at -20°C to -80°C.
