Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278

Human

CRH045 pdf (datasheet)

100 μg

$472.00 BUY

CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

Inducible T-cell costimulator

Q9Y6W8

CRH045

CHO cells

Lyophilized from a 0.2 µm filtered solution containing PBS.

≥98% by SDS-PAGE

Measured by its ability to inhibit human T cell proliferation induced by Recombinant Human CD275/B7-H2:Fc (human) Chimera (cat # CRH038) in the presence of anti-CD3.

<0.06 EU/μg purified protein as determined by LAL test (Lonza).

Centrifuge vial briefly to consolidate the product. Reconstitute with 100 µl sterile water. Add 1X PBS to the desired protein concentration.

Lyophilized product is stable for at least 1 year after receipt when stored at -20°C to -80° C. Upon reconstitution, prepare aliquots of the stock solution and store at -20°C to -80°C for up to 3 month at -20°C. Avoid repeated freeze-thaw cycles.