Synonyms:
Growth/differentiation factor 5, Bone morphogenetic protein 14, BMP-14, Cartilage-derived morphogenetic protein 1, CDMP-1, Lipopolysaccharide-associated protein 4, LAP-4, LPS-associated protein 4, Radotermin
Description:
Growth differentiation factor 5 (GDF-5) is a member of the bone morphogenetic protein (BMP) and transforming growth factor beta (TGF-β) families and functions to regulate cell proliferation and differentiation in embryonic and adult tissues. GDF-5 is expressed in the central nervous system and promotes the survival of dopaminergic neurons in animal models of Parkinson's disease. GDF-5 is also important during chondrogenesis and chondrocyte differentiation.
Uniprot Name:
Growth/differentiation factor 5
Molecular Weight:
Dimer, 13.7/27.4 kDa (121/242 aa)
Formulation:
Lyophilized from a sterile-filtered solution containing 0.1% Trifluoroacetic Acid (TFA)
Purity:
≥95% by reducing and non-reducing SDS-PAGE, HPLC
Biological Activity:
ED50 < 1200 ng/ml, by alkaline phosphatase activity in ATDC5 cells.
Specific Activity:
≥ 1,000 U/mg
Endotoxin Level:
≤ 0.1 EU/µg by kinetic LAL analysis
Amino Acid Sequence:
MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFIDSA NNVVYKQY EDMVVESCGC R
Reconstitution:
Centrifuge vial prior to opening. Add sterile distilled water to reconstitute to a recommended concentration of 0.1 mg/mL and gently pipet solution up and down sides of vial. DO NOT VORTEX. Allow several minutes for reconstitution. A small amount of precipitate may be seen.
Storage/Stability:
Store at -20°C to -80°C for up to 1 year.
