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Recombinant Human FLT3 Ligand

Molecule:

FLT3L

Synonyms:

Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine

Species:

Human

Cat. No.:

CRF110B pdf (datasheet)

Quantity/Size:

10 μg

Price:

$240.00 BUY

Description:

Fms-related tyrosine kinase 3 ligand (FLT-3 ligand) is a growth factor that regulates hematopoietic cell proliferation. FLT-3 ligand signalling is transmitted through the fms-related tyrosine kinase 3 (FLT-3) receptor. FLT-3 ligand promotes the long-term expansion and differentiation of pro-B cells in the presence of interleukin 7 (IL-7) or in combination of IL-7 and interleukin 3 (IL-3).
Human FLT-3 ligand is active on mouse cells.

Entrez Symbol:

FLT3LG

Uniprot Name:

Fms-related tyrosine kinase 3 ligand

Uniprot ID:

P49771

Data PDF:

CRF110

Source:

E. coli

Molecular Weight:

Monomer, 17.7 kDa (155 aa)

Formulation:

Lyophilized from sterile-filtered 10 mM sodium phosphate, 50 mM NaCl, pH 7.5

Purity:

>95% by reducing and non-reducing SDS-PAGE

Biological Activity:

ED50 < 5 ng/ml, determined by dose-dependent proliferation of OCI-AML5 cells.

Specific Activity:

≥ 2.0 x 105 units/mg

Endotoxin Level:

≤1 EU/µg by kinetic LAL analysis

Amino Acid Sequence:

MTQDCSFQHS PISSDFAVKI RELSDYLLQD YPVTVASNLQ DEELCGGLWR LVLAQRWMER LKTVAGSKMQ GLLERVNTEI HFVTKCAFQP PPSCLRFVQT NISRLLQETS EQLVALKPWI TRQNFSRCLE LQCQPDSSTL PPPWSPRPLE ATAPT

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year. Upon reconstitution, prepare working aliquots and store at -20°C to -80°C. It is recommended that a carrier protein such as 0.1% HSA or BSA is added for long term storage. Avoid repeated freeze-thaw cycles.