Description:
FGF-17 is a heparin binding growth factor that is a member of the FGF family. Proteins of
this family play a central role during prenatal development and postnatal growth and
regeneration of a variety of tissues, by promoting cellular proliferation and differentiation.
FGF-17 signals through the FGFR 1c, 2c, 3c, and 4. FGF-17 signals induction and
patterning of embryonic brain.
Uniprot Name:
fibroblast growth factor 17
Molecular Weight:
22.7 kDa
Physical State:
Lyophilized
Formulation:
Lyophilized from 10 mM Tris, 30 mM NaCl, pH 8.0
Purity:
>95% by SDS-PAGE and HPLC analyses.
Biological Activity:
Assay #1: ED50 ≤ 0.5 ng/ml, determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. Assay #2: ED50 ≤ 10 ng/ml, determined by a cell proliferation assay using Balb/c 3T3 cells.
Specific Activity:
Assay #1: ≥ 2 x 106 units/mg Assay #2: ≥ 1 x 105 units/mg
Endotoxin Level:
< 1 EU/µg
Amino Acid Sequence:
MTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT
Storage/Stability:
Store at -20°C to -80°C.
