Recombinant Human Exosome Component 10, His Tag

Synonyms:

Exosome component 10, Autoantigen PM/Scl 2, Polymyositis/scleroderma autoantigen 100 kDa, PM/Scl-10

Species:

Human

Cat. No.:

CRP140B pdf (datasheet)

Quantity/Size:

20 μg

Price:

$500.00 BUY

Description:

Exosome component 10 is a nucleolar protein and represents one crucial component of the so-called "PM/Scl complex" or "nuclear exosome", which is an RNA-processing complex consisting of a number of exoribonucleases (not to be confused with certain multivesicular bodies which are shed by cultured cells into the culture fluid and are also called exosomes). Autoantibodies against EXOSC10 occur in patients suffering from polymyositis, scleroderma or polymyositis/scleroderma overlap syndromes. While antibodies to other components of the exosome complex (PM/Scl 75, several Rrp proteins) can be found in some sera, practically all patients with autoantibodies against the PM/Scl complex are positive for EXOSC10 antibodies, making this specificity an important marker. The presence of EXOSC10 autoantibodies is a comparatively "good" prognostic sign in polymyositis/scleroderma overlap syndrome unlike the poor prognosis that is seen when other myositis and systemic sclerosis-specific autoantibodies are present.

Concentration:

1 mg/ml, lot specific

Entrez Symbol:

EXOSC10

Uniprot ID:

Q01780

Data PDF:

CRP140

Source:

Sf9 insect cells

Molecular Weight:

120 kDa

Tag:

6X His

Formulation:

Sterile-filtered 20 mM HEPES, pH-7.5, 100 mM NaCl, 0.01 mM EDTA, 0.02% SDS

Purity:

> 95% as determined by SDS-PAGE

Storage/Stability:

Store at -20°C to -80°C

Application notes:

Binds IgG-type human auto-antibodies.

Application:

ELISA, WB