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Recombinant Human Dipeptidyl Peptidase 4

Synonyms:

Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26

Species:

Human

Cat. No.:

CRG508B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$5,205.00 BUY

Description:

Dipeptidyl Peptidase 4 is a lymphocyte cell surface antigen which is increased during T-cell activation and is also expressed in other tissues, such as placenta, kidney, etc. It is an atypical serine protease which has been implicated in a variety of biological functions including diabetes, rheumatoid arthritis, T-cell activation, cell-to-cell adhesion, and recently in HIV infection. DPP4 cleaves X-proline dipeptides from the N-terminus of polypeptides. There are over 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuropeptides. DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and GLP-1.

Entrez Symbol:

DPP4

Uniprot Name:

Dipeptidyl peptidase 4

Uniprot ID:

P27487

Data PDF:

CRG508

Source:

Insect cells

Molecular Weight:

85.4 kDa (737 aa, 39-766)

Tag:

C-terminal 6X His

Formulation:

Sterile filtered 20 mM Tris-HCl, pH 8.0, 100 mM NaCl, 1 mM EDTA, 10% glycerol

Purity:

> 95% by SDS-PAGE

Biological Activity:

One unit will hydrolyze 1 mmole of p-nitroaniline per minute at pH8.0 at 37°C using 1mM of Gly-Pro p-nitroanilde as a substrate.

Specific Activity:

>200 Units/mg

Storage/Stability:

Store at -80°C up to 1 year