Recombinant Human CXCL16, C-His (Active)

Synonyms:

C-X-C motif chemokine 16, Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein, SR-PSOX, Small-inducible cytokine B16

Species:

Human

Cat. No.:

AHJ55601B pdf (datasheet)

Quantity/Size:

100µg

Price:

$725.00 BUY

Description:

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal "mucin-like stalk" sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog).

Entrez Symbol:

CXCL16

Uniprot Name:

C-X-C motif chemokine 16

Uniprot ID:

Q9H2A7

Source:

Mammalian cells

Molecular Weight:

20.5 kDa, predicted

Tag:

C-terminal His

Formulation:

Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol

Purity:

> 90% as determined by SDS-PAGE

Biological Activity:

ED50 = 10-50 ng/ml, determined by the ability to chemoattract mouse pro-B cells (BaF3) transfected with mouse CXCR6

Endotoxin Level:

< 0.1 EU/mg by LAL analysis

Amino Acid Sequence:

A DNA sequence encoding the human CXCL16 (Pro49-Tyr224) was fused with a C-terminal His tag

Reconstitution:

Reconstitute in sterile water for a stock solution.

Storage/Stability:

Store as supplied at -20°C to -80°C for up to 1 year.

Application:

Functional assay