Recombinant Human Eotaxin-2/CCL24

Molecule:

Eotaxin 2

Synonyms:

Ckb-6, MPIF-2, MPIF2, SCYA24, CK-beta-6, eotaxin-2, myeloid progenitor inhibitory factor 2, small inducible cytokine A24, small inducible cytokine subfamily A (Cys-Cys), member 24

Species:

Human

Cat. No.:

CRE001C pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$2,700.00 BUY

Description:

Recombinant Human Eotaxin-2/CCL24 is a single non-glycosylated polypeptide chain containing 78 amino acids.

Background: Eotaxin-2 (CCL24) is a novel CC chemokine recently identified. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation).

Entrez Symbol:

CCL24

Uniprot Name:

C-C motif chemokine 24

Uniprot ID:

O00175

Data PDF:

CRE001

Source:

E. coli

Molecular Weight:

~8.8 kDa

Formulation:

Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.

Purity:

>97% by SDS-PAGE and HPLC analyses.

Biological Activity:

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50-100 ng/ml.

Endotoxin Level:

Less than 1 EU/μg of rHuEotaxin-2/CCL24 as determined by LAL method.

Amino Acid Sequence:

VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKAGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA

Reconstitution:

Centrifuge vial prior to opening. Add sterile distilled water or aqueous buffer to a concentration of 0.1-1.0 mg/ml. Further dilutions should be made in appropriate buffered solutions.

Storage/Stability:

This lyophilized preparation is stable at 2-4°C, but should be kept desiccated at -20°C for long term storage. Upon reconstitution, the preparation is stable for up to one week at 2-4°C.