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Recombinant Human Cardiac Troponin I

Synonyms:

Troponin I cardiac muscle, Cardiac troponin I

Species:

Human

Cat. No.:

CRT134B pdf (datasheet)

Quantity/Size:

50 μg

Price:

$585.00 BUY

Description:

Troponin I (TnI), troponin T (TnT) and troponin C (TnC) form the troponin complex of the thin filaments of striated muscle. TnI is acts as the inhibitory subunit by blocking actinmyosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains 3 genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TNNI3 gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in the TNNI3 gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).

Entrez Symbol:

TNNI3

Uniprot Name:

Troponin I cardiac muscle

Uniprot ID:

P19429

Data PDF:

CRT134

Source:

E. coli

Molecular Weight:

24 kDa (210 aa) monomer

Formulation:

Sterile filtered liquid in 6 M urea, 50 mM Tris-HCl, pH 8.0

Purity:

>95% by SDS-PAGE analyses

Amino Acid Sequence:

MADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK TLLLQIAKQE LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL HARVDKVDEE RYDIEAKVTK NITEIADLTQ KIFDLRGKFK RPTLRRVRIS ADAMMQALLG ARAKESLDLR AHLKQVKKED TEKENREVGD WRKNIDALSG MEGRKKKFES

Storage/Stability:

Store at 2-8°C if the entire vial will be used within 2-4 weeks. For longer storage it is recommended to add a carrier protein (0.1% HSA or BSA) and store in working aliquots at -20°C to 80°C. Avoid repeated freeze-thaw cycles.