Adipocyte complement-related 30 kDa protein, ACRP30, Gelatin-binding protein, Adipocyte, C1q and collagen domain-containing protein

Human

CRA200C pdf (datasheet)

1.0 mg

$3,695.00 BUY

Adiponectin is a 30 kDa multimeric protein and is secreted mainly by white adipose tissue, although other tissues express low levels of adiponectin too. Full-length human adiponectin comprises 244 amino acid residues, including a N-terminal hyper-variable region (amino acids from 1–18), followed by a collagen-like domain structurally homologous with collagen VIII and X, consisting of 22 Gly-XY repeats, and a C-terminal C1q-like globular domain (amino acids from 108–244). In contrast to humans, mouse adiponectin is a 247 amino acid long protein. Adiponectin is secreted from adipocytes into the bloodstream as three oligomeric complexes, including trimer (67 kDa), hexamer (140 kDa), and a HMW (300 kDa) multimer comprising of at least 18 monomers. The monomeric form of adiponectin is undetectable in native conditions. Adiponectin is thought to play an important role in hyperglycemia, insulin resistance, cognitive decline in obesity, and signals through receptors, AdipoR1 and AdipoR2. T-cadherin as a receptor for hexameric and HMW forms of adiponectin.

ADIPOQ

Adiponectin

Q15848

CRA200

E. coli

25.1 kDa (aa 15-244)

Liquid in PBS, 1 mM DTT, pH 7.4

> 90% as determined by SDS-PAGE analysis

< 0.1 ng/µg of ACRP30

MGHDQETTTQ GPGVLLPLPK GACTGWMAGI PGHPGHNGAP GRDGRDGTPG EKGEKGDPGL IGPKGDIGET GVPGAEGPRG FPGIQGRKGE PGEGAYVYRS AFSVGLETYV TIPNMPIRFT KIFYNQQNHY DGSTGKFHCN IPGLYYFAYH ITVYMKDVKV SLFKKDKAML FTYDQYQENN VDQASGSVLL HLEVGDQVWL QVYGEGERNG LYADNDNDST FTGFLLYHDT N

Store in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.