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Rat Anti-Mouse Axl (Clone 10E7) mAb

Synonyms:

Receptor protein-tyrosine kinase

Species:

Mouse

Cat. No.:

CMA114 pdf (datasheet)

Quantity/Size:

100 μg

Price:

$800.00 BUY

Description:

Rat Anti-Mouse Axl was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified recombinant mouse Axl extracellular domain. IgG1 fraction of the cell culture supernatant was purified by Protein G affinity chromatography.

Axl is a member of the receptor tyrosine kinase subfamily that includes Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse,Brt) and Mer. Although it is similar to other receptor tyrosine kinases, the Axl protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. The AXL receptor transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growtharrest-specific gene 6 (GAS6). It is involved in the stimulation of cell proliferation.

Uniprot Name:

Receptor protein-tyrosine kinase

Uniprot ID:

Q6PE80

Data PDF:

CMA114

Specificity:

Mouse Axl

Host Species:

Rat

Immunogen:

Mouse Axl extracellular domain

Isotype:

IgG1

Clone:

10E7

Formulation:

Lyophilized from sterile filtered PBS

Purification:

Protein G affinity chromatography from tissue culture supernatant

Reconstitution:

Centrifuge vial prior to opening. Reconstitute with 500 µL sterile water to a final concentration of 200 μg/mL.

Application notes:

Western blot: suggested dilution 1:100-1000

Storage/Stability:

Upon receipt, store at -80°C for at least 1 year. After reconstitution, store in working aliquots at -80°C for up to six months. Avoid repeated freeze-thaw cycles.