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Superoxide dismutase (SOD) is an important antioxidant that protects many types of cells from superoxide anion radical by partitioning O-2 into O2 and H2O2. There are three major families of superoxide dismutase, depending on the protein fold and the metal cofactor: the Cu/Zn type used by eukaryotes (SOD1 human cytoplasm, SOD3 human extracellular) , Iron type (bacteria, chloroplasts) and Manganese type (bacteria, mitochondria - as SOD2 in humans), and the Nickel type (prokaryotes).