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Native Human Pepsinogen II

Molecule:

Pepsinogen II

Synonyms:

Gastricsin, Pepsinogen C, EC:3.4.23.3

Species:

Human

Cat. No.:

CNH003A pdf (datasheet)

Quantity/Size:

100 μg

Price:

$700.00 BUY

Description:

Human Pepsinogen II/PGC is an aspartic proteinase that belongs to the peptidase family A1. PGC is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. PGC is synthesized as an inactive zymogen that includes a highly basic pro-segment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the pro-segment that is carried out by the enzyme itself. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

Entrez Symbol:

PSC

Uniprot Name:

Gastricsin

Uniprot ID:

P20142

EC number:

EC:3.4.23.3

Data PDF:

CNH003

Source:

Human Gastric Mucosa

Molecular Weight:

40,600

Formulation:

Lyophilized from Tris chloride, pH 8.5.

Purity:

> 90% by SDS-PAGE, may contain minor cleavage products. Identity confirmed by Western blot.

Biological Activity:

One unit will produce a ΔA280 of 0.001 per minute at pH 2.0 and 37°C, measured as TCA-soluble products from hemoglobin.

Specific Activity:

> 1,000 U/mg protein (after activation)

Reconstitution:

After reconstitution maintain at or above pH 8.0 to avoid activation.

Storage/Stability:

Store at -20°C for up to 1 year.