Native Human Platelet Glycoprotein IIb/IIIa

Synonyms:

Integrin alpha-IIb, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, Integrin beta-3, Platelet membrane glycoprotein IIIa, GPIIIIa, CD61

Species:

Human

Cat. No.:

CSI20171B pdf (datasheet)

Quantity/Size:

2 mg

Price:

Please Inquire

Description:

Platelet membrane glycoproteins IIb and IIIa (GPIIb and GPIIIa), also known as integrin αIIbβ3 is an integrin complex found on platelets. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.

Concentration:

> 1.0 mg/ml, lot specific

Entrez Symbol:

ITGA2B, ITGB3

Uniprot Name:

Integrin alpha-IIb, Integrin beta-3

Uniprot ID:

P08514, P05106

Data PDF:

CSI20171

Source:

Human plasma

Molecular Weight:

GPIIb: disulfide-linked subunits 125 kDa, 23 kDa, reducing conditions
GPIIIa: monomer 108 kDa, reducing conditions

Formulation:

0.02M Tris-HCl, 0.1M NaCl, 0.1% Triton X-100, 0.001M CaCl2, 0.05% NaN3, 50% glycerol, pH 7.4

Purity:

>95% by SDS-PAGE analysis

Storage/Stability:

Store at -80°C for up to 1 year.