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Native Human Complement Component C1q

Synonyms:

Complement C1q

Species:

Human

Cat. No.:

CRC162B pdf (datasheet)

Quantity/Size:

1.0 mg

Price:

$655.00 BUY

Description:

Human Complement Component 1q (C1q) is a high molecular weight complex of six trimers, each consisting of an A, B, and C chain. Complement C1 is the first component in the classical complement cascade and circulates in plasma as a calcium-dependent complex of C1q, C1r, and C1s. C-terminal C1q globular domains bind to Fc regions of IgM or IgG present in immune complexes while N-terminal C1q collagen-like regions interact with the C1r2C1s2 proenzyme complex. C1q circulates in normal serum at 113 ug/ml. Patients deficient in C1q are prone to systemic lupus erythematosus (SLE) and glomerulonephritis as well as recurrent infection and skin lesions.

Concentration:

1.0 mg/ml, lot specific

Uniprot Name:

Complement C1q subcomponent subunit A, B, C

Uniprot ID:

P02745, P02746, P02747

Data PDF:

CRC162

Source:

Human Serum

Molecular Weight:

410 kDa

Formulation:

Sterile-filtered 0.01M HEPES, 0.3M NaCl, pH 7.2

Available containing 40% glycerol by request.

Purity:

> 95% by SDS-PAGE

Specific Activity:

> 150,000 U/mg, a unit defined as the amount of functional C1q needed to lyse 50% of 3 x 107 antibody-sensitized sheep erythrocytes.   

Lot specific, typically > 500,000 U/mg.

Storage/Stability:

Upon receipt store unopened at -80°C for up to 1 year. Upon initial thaw, prepare aliquots of the stock solution and store at -80°C.