Complement C3c, Complement component 3c

Human

CSI19505 pdf (datasheet)

250 μg

$570.00 BUY

C3c is derived from iC3b (inactivated C3b) by proteolytic cleavage. iC3b is created by cleavage of C3b by factor I in the presence of factor H, CR1 or MCP. C3c can be produced by an additional cleavage by factor I if the iC3b is bound to CR1. Factor H cannot serve as a cofactor for this cleavage. C3c can also be produced by the action of trypsin-like proteases on iC3b. If the C3b precursor was attached to a surface, then the iC3b will remain attached to that surface and when iC3b is cleaved the C3c is released into the surrounding solution while the C3dg/C3d fragment remains on that surface. The breakdown of fluid phase C3b is similar, but in this case both C3c and C3dg/C3d are soluble fragments.

1.0 mg/ml, lot specific

C3

Complement C3

P01024

CSI19505

Human Serum

139 kDa three chains

Sterile-filtered PBS, pH 7.2

>90% by SDS-PAGE, trace IgG, IgA, IgM, albumin, C5, Factor B, Factor H, Factor I by immunochemistry.

Store as supplied at -80°C for up to 1 year.