Complement C3a, Complement component 3a

Human

CSI19501 pdf (datasheet)

50 μg

$500.00 BUY

Native human C3a is prepared by cleavage of human C3 protein by a human C3 convertase. C3a is a member of the anaphylatoxin family of three proteins (C3a, C4a and C5a) produced by the activation of complement. Many of the biological functions of C3a are similar to those of C5a, but C3a is approximately 10- to 20-fold less active per microgram than C5a. C3a mediates many inflammatory responses including smooth muscle contraction, vasodilation, increased vascular permeability, and release of histamine from mast cells and basophils. In contrast to C5a, C3a does not exhibit significant neutrophil stimulating activities and does not induce chemotaxis, granule release or superoxide production. C3a acts through the C3a Receptor (C3aR) which is a G-protein coupled receptor found widely distributed on peripheral tissues, lymphoid cells (neutrophils, monocytes, and eosinophils) and in the central nervous system (astrocytes, neurons and glial cells). These activities of C3a are inactivated by removal of the C-terminal arginine and this occurs rapidly in plasma due to the action of carboxypeptidase N.

0.5 mg/ml, lot specific

C3

Complement C3

P01024

CSI19501

Human Serum

9089 Da (77 aa) monomer

Sterile-filtered PBS, pH 7.2

>95% by SDS-PAGE, < 2% desArg by HPLC

Store as supplied at -80°C for up to 1 year.