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Native Human Chorionic Gonadotropin subunit beta High Purity

Synonyms:

beta hCG, CG-beta

Species:

Human

Cat. No.:

CSI13970A pdf (datasheet)

Quantity/Size:

100 μg

Price:

$280.00 BUY

Description:

Human chorionic gonadotropin is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Increased levels of beta hCG indicates an implanted blastocyst and mammalian embryogenesis. Human chorionic gonadotropin can be used as a tumor marker as the β subunit is secreted by some cancers including seminoma, choriocarcinoma, germ cell tumors, hydatidiform mole, teratoma with elements of choriocarcinoma, and islet cell tumor. For this reason, a positive result in males can be a test for testicular cancer.

Entrez Symbol:

CGB3

Uniprot Name:

Choriogonadotropin subunit beta 3

Uniprot ID:

P0DN86

Data PDF:

CSI13970

Source:

Human urine

Molecular Weight:

Approximately 22 kDa

Formulation:

Lyophilized from 50mM Ammonium Bicarbonate

Purity:

> 98% by SDS-PAGE
1.0 mg beta hCG/mg protein by ELISA
LH <0.0001%
FSH <0.0001%
TSH <0.0001%

Reconstitution:

Gonadotropins are extremely labile in solution. Reconstitute immediately prior to use, at 1.0 mg/ml, in a neutral pH buffer such as PBS or TBS.  Include a carrier protein such as 1% BSA.  If your application precludes the use of a carrier protein, reconstitute product at 5 - 10 mg/ml. Avoid extreme high and low pH.    

Storage/Stability:

Store as supplied for up to 1 year at -20°C to -80°C.