Native Human Ceruloplasmin, Plasma

Molecule:

Ceruloplasmin

Synonyms:

Ceruloplasmin, Ferroxidase

Species:

Human

Cat. No.:

CSI19796B pdf (datasheet)

Quantity/Size:

10 mg

Price:

Please Inquire

Description:

Ceruloplasmin is a blue, copper binding glycoprotein involved in the peroxidation of Fe2+ transferrin to Fe3+ transferrin, without releasing radical oxygen species. It is an acute-phase reactant. Increased levels are associated with normal pregnancy, rheumatoid arthritis, and cirrhosis. Decreased levels are associated with hepatolenticular degeneration (Wilson's Disease). An elevated level of Cp is found in patients with progressive tumors. Additionally, because Cp is a prooxidant, an elevated level is a sign of cardiovascular disease. May also play a role in fetal lung development or pulmonary antioxidant defense.

Uniprot Name:

Ceruloplasmin

Uniprot ID:

P00450

Data PDF:

CSI19796

Source:

Human plasma

Molecular Weight:

132 kDa

Formulation:

Lyophilized from 50 mM potassium phosphate, 100 mM KCl, 5 mM EDTA, 20 mM EACA (ε-aminocaproic acid), pH 6.8.

Purity:

>95% by SDS-PAGE analysis

Reconstitution:

Centrifuge vial prior to opening. Reconstitute to the original volume with sterile, high purity water, followed by gentle mixing. Do not vortex. If further dilution is required use the same original formulation buffer. Exposure to sodium (such as sodium chloride, sodium phosphate, sodium azide) should be avoided as ceruloplasmin may precipitate under these conditions. Buffers should be pH-adjusted with potassium hydroxide (KOH)

Storage/Stability:

Store unopened at -20°C to -80°C for at least 1 year. Following reconstitution, store at
2-8oC. Freeze-thaw cycles contribute to degradation of ceruloplasmin.